THE HEPATOTOXIC AND NEPHROTOXIC EFFECTS OF ORAL ADMINISTRATION OF HERBALIFE® PRODUCTS IN MICE

Herbal and non-herbal supplements in mice

Autores

  • Larissa Côco Universidade Vila Velha https://orcid.org/0000-0003-1601-8419
  • Gabriela Coutinho
  • Adriélly Fiorese Santanna
  • Placielle Fiorezi Filete
  • Polianna da Silva Ferreira
  • Hildegardo Seibert França
  • Fausto Edmundo Lima Pereira
  • Bianca Prandi Campagnaro
  • Thiago de Melo Costa Pereira

Palavras-chave:

herbal products, non-herbal products , protein oxidation , hepatotoxicity

Resumo

The increase in the consumption of dietary supplements has been growing and the absence of pre-clinical studies that demonstrate the impact of the consequences of their chronic consumption is the biggest gap. Therefore, the objective of the present study was to evaluate the effects of supplements of chronic use of Herbalife® products (Shake and Tea). For this, the caffeine in the products was first quantified. Mice were separated into four groups: Control, Tea, Shake and Shake + Tea and treated for 28 days by gavage. The weight of the animals, the open field test, biochemical tests, morphometric analysis and the oxidative stress of the kidney and liver were evaluated. Our results showed the detection of caffeine in the Shake a 10-fold higher dose in tea samples. Animals exposed to the “Shake+Tea” association show changes in their behavior pattern. In addition, we observed an AST increase (+175%) in Shake + Tea for the control group, as well as a ~10-fold increase in AOPP in kidney tissue for all groups. Histopathological of liver and kidney and biochemical analysis tissue showed no changes in the experimental groups. Our results indicate that the chronic use of Herbalife® products contributes to changes in the pattern of motor behavior, increased AST and protein oxidation in renal tissue. In this sense, it is suggested that more experimental studies are needed to support the safety of these products that are widely consumed by the general population.

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Publicado

2022-01-11

Como Citar

Côco, L., Coutinho, G. ., Fiorese Santanna, A. ., Fiorezi Filete, P. ., da Silva Ferreira, P. ., Seibert França, H. ., Lima Pereira, F. E. ., Prandi Campagnaro, B., & de Melo Costa Pereira, T. (2022). THE HEPATOTOXIC AND NEPHROTOXIC EFFECTS OF ORAL ADMINISTRATION OF HERBALIFE® PRODUCTS IN MICE: Herbal and non-herbal supplements in mice. Revista Ifes Ciência , 8(1), 1-14. Recuperado de https://ojs.ifes.edu.br/index.php/ric/article/view/1680

Edição

Seção

Ciências Biológicas e Saúde