CORONAVIRUS AND ITS MAIN PROTEASE: AN INSIGHT FOR DRUGS DESIGN BY MOLECULAR DOCKING

Autores

  • Simone Queiroga Brito Gonçalves UFES
  • Eloi Alves da Silva Filho UFES
  • Osmair Vital de Oliveira IFSP
  • Arlan da Silva Gonçalves

DOI:

https://doi.org/10.36524/ric.v6i1.749

Palavras-chave:

Coronavirus, Protease, Molecular docking

Resumo

Many viruses need their sulphydryl groups to be reduced in order to be allowed to enter cells. SARS-CoV-2, which belongs to Coronaviridae family and is responsible for coronavirus disease 2019 or COVID-19, has cysteine-rich proteins in its capsid as the main CoV protease (MPRO), which must be intact and active maintaining the viral activity. Considering that MPRO is an important molecular target for development of antiviral drugs, this work motivation was the structural study of the possible ways of interaction between drugs and viral cysteines by molecular docking technique for design of new potential inhibitors of MPRO and its virulence.

Publicado

2020-06-13

Como Citar

Gonçalves, S. Q. B., da Silva Filho, E. A., de Oliveira, O. V. ., & Gonçalves, A. da S. (2020). CORONAVIRUS AND ITS MAIN PROTEASE: AN INSIGHT FOR DRUGS DESIGN BY MOLECULAR DOCKING. Revista Ifes Ciência , 6(1), 73-83. https://doi.org/10.36524/ric.v6i1.749

Edição

Seção

Artigos científicos