TY - JOUR AU - Gonçalves, Simone Queiroga Brito AU - da Silva Filho, Eloi Alves AU - de Oliveira, Osmair Vital AU - Gonçalves, Arlan da Silva PY - 2020/06/13 Y2 - 2024/03/29 TI - CORONAVIRUS AND ITS MAIN PROTEASE: AN INSIGHT FOR DRUGS DESIGN BY MOLECULAR DOCKING JF - Revista Ifes Ciência JA - Ifes Ciência VL - 6 IS - 1 SE - DO - 10.36524/ric.v6i1.749 UR - https://ojs.ifes.edu.br/index.php/ric/article/view/749 SP - 73-83 AB - <p>Many viruses need their sulphydryl groups to be reduced in order to be allowed to enter cells. SARS-CoV-2, which belongs to <em>Coronaviridae</em> family and is responsible for coronavirus disease 2019 or COVID-19, has cysteine-rich proteins in its capsid as the main CoV protease (M<sup>PRO</sup>), which must be intact and active maintaining the viral activity. Considering that M<sup>PRO </sup>is an important molecular target for development of antiviral drugs, this work motivation was the structural study of the possible ways of interaction between drugs and viral cysteines by molecular docking technique for design of new potential inhibitors of M<sup>PRO</sup> and its virulence.</p> ER -